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Lacunar infarction

MedGen UID:
137685
•Concept ID:
C0333559
•
Disease or Syndrome
Synonyms: Infarct, Lacunar; Infarction, Lacunar; Infarctions, Lacunar; Infarcts, Lacunar; Lacunar Infarct; Lacunar Infarction; Lacunar Infarctions; Lacunar Infarcts
SNOMED CT: Lacunar infarct (81037000); Lacunar infarction (230698000); LACI - Lacunar infarction (230698000); LI - Lacunar infarction (230698000)

Definition

Brain infarction that affects small subcortical vessels due to occlusion of a penetrating artery deep in the brain. It may lead to lacunar stroke. [from MeSH]

Professional guidelines

PubMed

Pathophysiology and Optimal Treatment of Intracranial Branch Atheromatous Disease.
Deguchi I, Takahashi S
J Atheroscler Thromb 2023 Jul 1;30(7):701-709. Epub 2023 May 13 doi: 10.5551/jat.RV22003. PMID: 37183021Free PMC Article
Update on diagnosis and differential diagnosis of vestibular migraine.
Shen Y, Qi X
Neurol Sci 2022 Mar;43(3):1659-1666. Epub 2022 Jan 11 doi: 10.1007/s10072-022-05872-9. PMID: 35015204
Antihypertensive treatment can prevent stroke and cognitive decline.
Sörös P, Whitehead S, Spence JD, Hachinski V
Nat Rev Neurol 2013 Mar;9(3):174-8. Epub 2012 Dec 18 doi: 10.1038/nrneurol.2012.255. PMID: 23247612

Recent clinical studies

Etiology

Intracerebral hemorrhage in CADASIL.
Palazzo P, Le Guyader G, Neau JP
Rev Neurol (Paris) 2021 Apr;177(4):422-430. Epub 2021 Jan 19 doi: 10.1016/j.neurol.2020.10.009. PMID: 33478738
Secondary stroke prevention.
Spence JD
Nat Rev Neurol 2010 Sep;6(9):477-86. Epub 2010 Aug 10 doi: 10.1038/nrneurol.2010.114. PMID: 20697424
Lacunar stroke.
Arboix A, Martí-Vilalta JL
Expert Rev Neurother 2009 Feb;9(2):179-96. doi: 10.1586/14737175.9.2.179. PMID: 19210194
Cerebral microhemorrhage.
Viswanathan A, Chabriat H
Stroke 2006 Feb;37(2):550-5. Epub 2006 Jan 5 doi: 10.1161/01.STR.0000199847.96188.12. PMID: 16397165
Platelets and stroke.
Smith NM, Pathansali R, Bath PM
Vasc Med 1999;4(3):165-72. doi: 10.1177/1358836X9900400307. PMID: 10512596

Diagnosis

Review of neuroimaging research progress of cerebral small vessel disease.
Wang J, Wang B, Wang K
Folia Neuropathol 2023;61(1):1-7. doi: 10.5114/fn.2023.124712. PMID: 37114955
Update on diagnosis and differential diagnosis of vestibular migraine.
Shen Y, Qi X
Neurol Sci 2022 Mar;43(3):1659-1666. Epub 2022 Jan 11 doi: 10.1007/s10072-022-05872-9. PMID: 35015204
Cerebral microhemorrhage.
Viswanathan A, Chabriat H
Stroke 2006 Feb;37(2):550-5. Epub 2006 Jan 5 doi: 10.1161/01.STR.0000199847.96188.12. PMID: 16397165
Long-term prognosis after lacunar infarction.
Norrving B
Lancet Neurol 2003 Apr;2(4):238-45. doi: 10.1016/s1474-4422(03)00352-1. PMID: 12849212
Stroke.
Nadeau SE
Med Clin North Am 1989 Nov;73(6):1351-69. doi: 10.1016/s0025-7125(16)30603-4. PMID: 2682065

Therapy

Antiplatelet Therapy or Not for Asymptomatic/Incidental Lacunar Infarction.
Bilski AE, Aparicio HJ, Gutierrez J, de Leeuw FE, Hilkens NA
Stroke 2023 Jul;54(7):1954-1959. Epub 2023 May 16 doi: 10.1161/STROKEAHA.122.040444. PMID: 37191009Free PMC Article
Review of neuroimaging research progress of cerebral small vessel disease.
Wang J, Wang B, Wang K
Folia Neuropathol 2023;61(1):1-7. doi: 10.5114/fn.2023.124712. PMID: 37114955
Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial.
Kim BC, Youn YC, Jeong JH, Han HJ, Kim JH, Lee JH, Park KH, Park KW, Kim EJ, Oh MS, Shim Y, Lee JM, Choi YH, Park G, Kim S, Park HY, Yoon B, Yoon SJ, Cho SJ, Park KC, Na DL, Park SA, Choi SH
Stroke 2022 Mar;53(3):698-709. Epub 2021 Nov 16 doi: 10.1161/STROKEAHA.121.035766. PMID: 34781708
Homocysteine lowering for stroke prevention: Unravelling the complexity of the evidence.
Spence JD
Int J Stroke 2016 Oct;11(7):744-7. Epub 2016 Jul 26 doi: 10.1177/1747493016662038. PMID: 27462097
Platelets and stroke.
Smith NM, Pathansali R, Bath PM
Vasc Med 1999;4(3):165-72. doi: 10.1177/1358836X9900400307. PMID: 10512596

Prognosis

Pathophysiology and Optimal Treatment of Intracranial Branch Atheromatous Disease.
Deguchi I, Takahashi S
J Atheroscler Thromb 2023 Jul 1;30(7):701-709. Epub 2023 May 13 doi: 10.5551/jat.RV22003. PMID: 37183021Free PMC Article
Retinal Vascular Signs and Cerebrovascular Diseases.
Rim TH, Teo AWJ, Yang HHS, Cheung CY, Wong TY
J Neuroophthalmol 2020 Mar;40(1):44-59. doi: 10.1097/WNO.0000000000000888. PMID: 31977663
Lacunar stroke.
Arboix A, Martí-Vilalta JL
Expert Rev Neurother 2009 Feb;9(2):179-96. doi: 10.1586/14737175.9.2.179. PMID: 19210194
Cerebral microhemorrhage.
Viswanathan A, Chabriat H
Stroke 2006 Feb;37(2):550-5. Epub 2006 Jan 5 doi: 10.1161/01.STR.0000199847.96188.12. PMID: 16397165
Long-term prognosis after lacunar infarction.
Norrving B
Lancet Neurol 2003 Apr;2(4):238-45. doi: 10.1016/s1474-4422(03)00352-1. PMID: 12849212

Clinical prediction guides

Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.
Kijpaisalratana N, Ament Z, Bevers MB, Bhave VM, Garcia Guarniz AL, Couch CA, Irvin MR, Kimberly WT
JAMA Netw Open 2023 Aug 1;6(8):e2330446. doi: 10.1001/jamanetworkopen.2023.30446. PMID: 37610752Free PMC Article
Review of neuroimaging research progress of cerebral small vessel disease.
Wang J, Wang B, Wang K
Folia Neuropathol 2023;61(1):1-7. doi: 10.5114/fn.2023.124712. PMID: 37114955
Cerebral and Retinal Infarction in Bicuspid Aortic Valve.
Huntley GD, Michelena HI, Thaden JJ, Alkurashi AK, Pislaru SV, Pochettino A, Crestanello JA, Maleszewski JJ, Brown RD Jr, Nkomo VT
J Am Heart Assoc 2023 Apr 4;12(7):e028789. Epub 2023 Mar 21 doi: 10.1161/JAHA.122.028789. PMID: 36942747Free PMC Article
Retinal Vascular Signs and Cerebrovascular Diseases.
Rim TH, Teo AWJ, Yang HHS, Cheung CY, Wong TY
J Neuroophthalmol 2020 Mar;40(1):44-59. doi: 10.1097/WNO.0000000000000888. PMID: 31977663
Cerebral microhemorrhage.
Viswanathan A, Chabriat H
Stroke 2006 Feb;37(2):550-5. Epub 2006 Jan 5 doi: 10.1161/01.STR.0000199847.96188.12. PMID: 16397165

Recent systematic reviews

Editor's Choice - Asymptomatic Carotid Stenosis and Cognitive Impairment: A Systematic Review.
Paraskevas KI, Faggioli G, Ancetti S, Naylor AR
Eur J Vasc Endovasc Surg 2021 Jun;61(6):888-899. Epub 2021 May 6 doi: 10.1016/j.ejvs.2021.03.024. PMID: 33966986
Human brain pathology in myotonic dystrophy type 1: A systematic review.
Weijs R, Okkersen K, van Engelen B, Küsters B, Lammens M, Aronica E, Raaphorst J, van Cappellen van Walsum AM
Neuropathology 2021 Feb;41(1):3-20. doi: 10.1111/neup.12721. PMID: 33599033Free PMC Article
Intracerebral hemorrhage in CADASIL.
Palazzo P, Le Guyader G, Neau JP
Rev Neurol (Paris) 2021 Apr;177(4):422-430. Epub 2021 Jan 19 doi: 10.1016/j.neurol.2020.10.009. PMID: 33478738
Stroke in Arab countries: a systematic literature review.
Benamer HT, Grosset D
J Neurol Sci 2009 Sep 15;284(1-2):18-23. Epub 2009 May 9 doi: 10.1016/j.jns.2009.04.029. PMID: 19428027
Comparing risks of death and recurrent vascular events between lacunar and non-lacunar infarction.
Jackson C, Sudlow C
Brain 2005 Nov;128(Pt 11):2507-17. Epub 2005 Sep 29 doi: 10.1093/brain/awh636. PMID: 16195245Free PMC Article

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